COMETS is a software platform for performing computer simulations of metabolism in spatially structured microbial communities. It is based on stoichiometric modeling of the genome-scale metabolic network of individual microbial species (using dynamic flux balance analysis), and on a discrete approximation of convection-diffusion equations.

The first version of COMETS became publicly available in 2014, and was associated with the following paper: Harcombe et al., Metabolic Resource Allocation in Individual Microbes Determines Ecosystem Interactions and Spatial Dynamics, Cell Reports, 2014.

COMETS 2 is the newest version of COMETS, which was developed as a partnership between researchers at Boston University, Yale University and the University of Minnesota.

COMETS in journal articles:

Cell Report, 2014

PLOS Biology 2016

ISME Journal, 2018

mSystems, 2018

PNAS, 2018

Biomedical Physics And Engineering Express, 2018